How it’s going

Before Don't Die, I built in payments, founding Braintree Venmo.

Excited for the next frontier with Stable and @paoloardoino

Nietzsche agrees with me on sleep

ht @Grimezsz

@DanielvsBabylon bro why are you calling me satan when I'm telling you to go to bed on time

@will__mcevoy we do need new katechons

4/ Significance and caveats of the OpenAI-Retro approach

Advantages to regenerative medicine: The discovery removes long-standing barriers to regenerative medicine by enabling a scalable, efficient, and safer supply of iPSCs for use in tissue, organ, and cell therapy

2/ 1/ OpenAI × Retro: Breaking the Bottleneck

To overcome these barriers, OpenAI built GPT-4b micro, a compact model derived from GPT-4o but specialized for protein design.

Initialized from a scaled-down GPT-4o, GPT-4b micro was trained by blending protein sequences, structural

3/ Key Results (AI-generated KLF4 and SOX2 vs. traditional OSKM Controls)

Variant hit rate
+ Expert-driven design of OSKM: < 10% of engineered variants outperform wild-type.
+ GPT-4b micro: 30% of SOX2 and 50% of KLF4 variants outperformed wild-type.

Pluripotency induction

0/ AI Redesigns the Engines of Cellular Reprogramming

OpenAI and Retro Biosciences reported a landmark achievement: using a domain-specialized protein design model, GPT-4b micro, they created engineered reprogramming factors that deliver over 50× higher efficiency in generating