Skip to content
POSTS
  • POSTS
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Two weeks without mobile internet improved mental health more than antidepressants and reversed roughly 10 years of attentional decline.

    Screen time dropped 49% (314 to 161 min/day).

    Tweet media
    Apr 18, 2026 141 11 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Pregnancy is severely underappreciated in our society. Most women don't get the guidance they need from doctors. Self experimentation gives the power back.

    Apr 17, 2026 85 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I'm in a bad mood right now because I didn't get to exercise this morning. I had a bunch of stuff done to my face yesterday and had to take the day off.

    I become an entirely different person without exercise. I don't like this guy much.

    Apr 17, 2026 193 6 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    No sex with Kate.
    5 day abstinence.
    For an experiment.
    Goodnight everyone.

    Apr 17, 2026 8421 155 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Most people might miss the biggest benefit of sauna

    You need to get really really hot…

    Your core body temperature needs to hit 102.4°F (39°C).

    For reference, a fever is anything above 100.4°F (38°C)

    So I swallowed a temperature monitoring pill. It goes through your digestive

    Tweet media
    Apr 16, 2026 4388 194 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @PharmapunkTV Appreciate the detailed protocol; this is close to where we landed, yet we went a different direction.

    Sermorelin has the cleanest safety profile of the GHRH analogs, real FDA history (Geref), decades of data. No argument. But the clinical data showing roughly 50% IGF-1 increase

    Apr 16, 2026 6 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @AbudBakri That was our initial instinct too. But Ionescu & Frohman (2006) showed pulsatility is preserved even under continuous DAC stimulation; pulse frequency and magnitude unchanged, with a 7.5-fold increase in trough GH.

    Teichman et al. (2006) showed IGF-1 elevation of 1.5–3x

    Apr 16, 2026 12 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @ender_wiggin_ Appreciate the concern. Stacking risk is real, and not all peptide sources are to be trusted. We take both seriously. Every protocol is built incrementally, taking into account the entire backdrop of interventions already in the stack, starting at half dose with predefined stop

    Apr 16, 2026 10 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @ElevateBiohack We chose GHRH agonism over exogenous GH because it preserves natural pulsatility. Ionescu & Frohman (2006) showed pulsatile GH secretion persists even under continuous CJC-1295 DAC stimulation; baseline increases while the daily rhythm stays intact. Exogenous GH overrides that

    Apr 16, 2026 10 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @askgodswill Fully aware. This is a short-term investigational protocol testing whether pulsatile GHRH stimulation delivers measurable benefits to sleep architecture, lean mass, performance, tissue repair, and overall well-being and whether tirzepatide offsets the metabolic cost in real time.

    Apr 16, 2026 13 0 View on X
  • Posts navigation

    • 1
    • 2
    • 3
    • …
    • 1,436
    • »
    © 2025 Bryan Johnson