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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @seloesque Because I'm neurotic and was so dissatisfied with how I wrote it that I had to delete it. It's a big deal and I wanted the scientists' work to be presented in a compelling way. My brain was fried from working 14 hours, so I wanted to sleep before drafting again.

    Apr 20, 2026 32 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    One dose:
    > 46% more dendritic spines in prefrontal cortex
    > 100x more potent than ketamine as an antidepressant

    What is it?

    LSD with a two atom swap.

    > no trip
    > no hallucinations
    > no schizophrenia signature

    It's called JRT.

    Tweet media
    Apr 20, 2026 66 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Salt has been blamed as the culprit for damaging your arteries.

    A new mouse study puts salt-sensitive hypertension in context.

    Salt doesn't do it directly, it triggers your immune system to do it.

    4 weeks on a high-salt diet (8% NaCl) cut vasodilation by over 20% and spiked

    Tweet media
    Apr 20, 2026 9 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Salt has been blamed as he culprit for damaging your arteries.

    A new mouse study challenges that.

    Salt doesn't do it directly, it triggers your immune system to do it.

    4 weeks on a high-salt diet (8% NaCl) cut vasodilation by over 20% and spiked senescence markers in blood

    Tweet media
    Apr 20, 2026 83 6 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @karpathy appreciate you putting me down the path, it’s a new world for me

    Apr 20, 2026 9 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Best things you can do for health.

    Decide:
    + when to sleep
    + when to exercise
    + what to eat

    Routine does the heavy lifting.

    Apr 19, 2026 246 15 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I've done ketamine.
    I've done psilocybin.
    I've done 5-MeO-DMT.

    I measured my brain before and after all of them.

    Now UC Davis swapped two atoms in LSD and got 46% dendritic spine regrowth and 18% synapse formation. Without the trip.

    100x more potent than ketamine as an

    Tweet media
    Apr 19, 2026 26 5 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I got C-holed.

    Suffered sleep consequences.
    I busted my screens-off rule.
    Turned down socializing.
    Fell behind on work.
    Kate is now upset.

    AI is preposterous. As close to magic as I’ve experienced (except a seed becoming a tree and a zygote becoming a baby).

    It started on

    Apr 19, 2026 38 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    To predict the next dominant societal philosophy, just measure the depth of the technological disruption preceding it. Every major shift breaks something and then ideology rushes in to patch what was lost.

    For example, the printing press broke the Church's monopoly on truth and

    Apr 19, 2026 29 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I used to believe the person experiencing the craving should be the one deciding whether to act on it. That's kinda like letting a drowning person design the rescue plan.

    Apr 18, 2026 90 3 View on X
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