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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    12/ Rapamycin:
    Every two weeks, I take 13 mg of gastro protected Rapamune (Rx required). Rapamycin is used to prevent organ transplant rejection and has possible anti-aging effects. To personalize dose and measure for safety and efficacy...

    Jun 5, 2023 14 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    13/ Rapamycin (cont'd)
    ...we've measured my Rapamycin blood levels 90 min, 4.1 days and 13 days post administration.  Rapamycin was discovered in the bacteria of Rapa Nui island (image).

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    Jun 5, 2023 28 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    10/ IGF-1
    For the HGH protocol to rejuvenate the Thymus, we are also monitoring IGF-1 (Insulin like growth factor 1). The objective is to pulse IGF-1 levels to above 150 ng/mL during the course of the therapy. Results 👇

    Jun 5, 2023 17 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    11/
    63% increase in IGF-1 one month starting .6 mg HGH 5x week.

    Historical (ng/mL) data:
    Nov '20: 123
    Aug '21: 131
    Jan '22: 103
    Dec '22: 94
    Mar '23: 153

    Potentially long term ideal range for people age 45+ is 75-150 ng/mL based on clinical outcome epidemiological studies

    Jun 5, 2023 15 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    8/ (blood glucose cont'd)
    ...HGH can negatively affect insulin sensitivity:

    My blood glucose (BG) levels were 94% in optimal range 70-125 mg/dL. 97% in Mar 2021.

    Result: no clinically relevant difference of HGH on blood glucose.

    Jun 5, 2023 15 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    9/ (blood glucose cont'd)
    What I do for routine blood glucose optimization: Metformin SR, Acarbose, Ginger. Cinnamon, Turmeric, Garlic, Zinc, D3, DHEA, + low GI/GL diet + CRON.

    Jun 5, 2023 29 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    7/
    Blood Glucose: started Human Growth Hormone (HGH) in February 2023 (.6 mg 5x wk) for Thymus rejuvenation (the thymus is a gland in the chest responsible for the immune system). Part of our safety and efficacy monitoring includes measuring blood glucose levels as...

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    Jun 5, 2023 27 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    6/
    My weekly exercise summary:
    Moderate: 4 hr 37 min (106-159 bpm)
    Vigorous: 1 hr 25 min (159 bpm +)
    Total Moderate + Vigorous: 6 hr 2 min

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    Jun 5, 2023 38 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/
    . Leg press single rep max 800 lbs, top 1-2% 18 yr olds
    . Previous 2021: 780 lbs
    . Leg press to weight ratio: 1.91

    Ref to age 18 because that's when single rep max to body weight ratio (bench and leg press) starts declining in men as per ACSM reference range.

    Jun 5, 2023 27 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/
    . Bench press single rep max 240 lbs (top 10% of 18 yr olds)
    . Previous 2021: 235 lbs
    . Bench press to weight ratio: 1.13

    Ref to age 18 because that's when single rep max to body weight ratio (bench and leg press) starts declining in men as per ACSM reference range.

    Jun 5, 2023 46 0 View on X
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