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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @Jawsawn This will spike your blood glucose and insulin, reduce your overnight glycemic control and increase hunger the following day.

    Eating this before bed keeps your body on day mode, raising core body temp and sympathetic activity which delay melatonin release and reduces sleep.

    Jul 25, 2025 5 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ Interpreting your VEGF results correctly

    While VEGF holds significant health and longevity indications, sudden, unexpected, and abnormal increases in VEGF beyond the normal range can signal disease, including tumors, peripheral vascular disease, or autoimmune diseases.

    Some

    Jul 25, 2025 2 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ My latest VEGF level compared to a healthy population

    Although VEGF function and signaling are reported to decline with age, serum VEGF levels do not appear to show a clear age-dependent decline. The normal range is between 62 and 707 pg/mL. Compared to a healthy cohort of

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    Jul 25, 2025 0 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ VEGF as a potential longevity marker and therapy

    A preclinical study indicated that VEGF gene therapy can reverse biological aging in multiple organs in mice, as well as reset several hallmarks of aging, including inflammation, declining mitochondrial function, and blood

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    Jul 25, 2025 2 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Last year, my serum VEGF was 22 pg/mL, which is below normal range. This was not ideal as VEGF is crucial for maintaining, remodeling, and growing existing blood vessels, as well as forming new ones (angiogenesis, neovascularization).

    Angiogenesis (new blood vessels) can

    Jul 25, 2025 3 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ HBOT and sauna dramatically increased my VEGF levels

    Following 60 HBOT sessions in late January 2025, my VEGF levels almost tripled from the baseline of 22 pg/mL, reaching 64 pg/mL, which is at the lower end of the normal range. My latest blood draw last week (July 16th)

    Jul 25, 2025 2 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    HBOT and sauna boosted VEGF 19x in 9 months

    + this hormone builds blood vessels
    + allowing more oxygen and nutrients to organs
    + keeps arteries flexible and youthful
    + slowing multiple aging processes 🧵

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    Jul 25, 2025 39 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    if blueprint doesnt work out

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    Jul 25, 2025 109 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @dhh hey david - been a minute. hope you're well.

    today's extremes will be normal tomorrow. these health things will also be automated so that people don't need to work so hard.

    i'm grateful people r pushing the frontiers of being health aware and learning what warrants attention

    Jul 24, 2025 4 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    reading ingredients in the kids aisle

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    Jul 24, 2025 104 3 View on X
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