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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ The marker has strong prognostic value in healthy people as well. A study found a simple p-Tau217 blood test to be equally predictive of future cognitive decline risk to much more complex brain imaging of Tau-tangles.

    May 19, 2025 18 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Cognitively unimpaired individuals in the highest 25% of pTau217 levels demonstrated a 57% elevated risk of future cognitive decline. This is comparable to the 61% increased risk observed in those with the highest 25% of Tau accumulation in pertinent brain areas (a…

    May 19, 2025 34 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    HBOT reduced a future dementia marker of mine by 28%.

    Details:
    + pTAU217 just got FDA-cleared for early Alzheimer’s screening. It also has prognostic value for healthy brains.

    + The FDA just approved approved pTAU217/A𝛃42 ratio as the first blood test for the early…

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    May 19, 2025 596 35 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Phosphorylated tau protein (p-TAU217) is a disease marker that accumulates as tangles in the brains of individuals with Alzheimer's disease. Elevated concentrations of p-TAU217 can also be detected in the blood, higher concentrations predict faster disease progression.

    May 19, 2025 30 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Skip the late latte.

    Caffeine after 2 PM can delay melatonin by hours. That means tossing, turning, and feeling wired when your body wants rest.

    May 19, 2025 1509 61 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    All my efforts around health, anti-aging and Don't Die are 100% about the human race living past the superintelligence event horizon.

    May 19, 2025 1884 71 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Do this one thing for your health: lower your resting heart rate before bed.

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    May 19, 2025 3338 213 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Society rebranded self destruction as pleasure.

    May 19, 2025 2979 374 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    If 10,000 hours is a path to greatness, where does one invest that time in 2025?

    May 19, 2025 1882 67 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    The worst selling product on X is kindness.

    May 19, 2025 2453 109 View on X
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