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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Sedentary behavior reduces mitochondrial function in skeletal muscle, leading to faster fatigue and reduced metabolic health. Just 2 weeks without exercise can drop mitochondrial density by 20-25%

    May 20, 2025 1986 157 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    A top adult animation reached out asking for usage rights to my media. They're going to roast me. I said yes. We'll see if it ends up in their cut.

    May 20, 2025 5092 48 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    this is your sign to stop doom scrolling and go to bed

    May 20, 2025 2207 69 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    The goal is to debate life's meaning.

    If you're dead, you can't debate anymore.

    Tweet media
    May 20, 2025 2249 55 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @zaidkdahhaj If your dumps are that fatty, you might have steatorrhea. Signs of fat-malabsorption that can point to pancreatic enzyme shortages, gallbladder or bile-duct issues, or other gut problems. Worth getting it checked out.

    May 19, 2025 689 5 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Did you know "sugar face" is a thing?

    Sugar leads to AGEs which leads to the yellowing of skin (“sugar face”) due to glycation-induced crosslinking.

    AGEs visibly degrade skin quality:
    + Collagen stiffens, your skin loses elasticity, leading to wrinkles.
    + Elastin breaks down…

    May 19, 2025 1304 93 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    An extended family member of mine was diagnosed with an aggressive cancer. He has days to live.

    Regular testing and early detection is the best way to avoid this.

    May 19, 2025 4736 86 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ HBOT reduced my blood p-TAU217 by 28% from 0.14 to 0.10 pg/mL.

    0.15 pg/mL is considered the upper range of healthy.

    May 19, 2025 39 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ The FDA has just approved the marketing of Lumipulse G test, which uses pTAU217/A𝛃42 as the first blood test for early detection of Alzheimer disease in people over 55, showing symptoms for the disease.

    May 19, 2025 22 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ The marker has strong prognostic value in healthy people as well. A study found a simple p-Tau217 blood test to be equally predictive of future cognitive decline risk to much more complex brain imaging of Tau-tangles.

    May 19, 2025 18 0 View on X
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