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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    This shows potential for Ozempic and other GLP1 receptor agonists as potential longevity drugs beyond their role as diabetes and obesity medication, and warrants more credibility to earlier claims that focused only on obese patients. Ref (5)

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    Oct 29, 2024 118 4 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Ozempic had better Alzheimer's disease protective advantage in women, and in the special case of SGLT2-inhibitors, the Ozempic advantage was exclusive in women, with SGLT2 inhibitors outperforming Ozempic slightly by 14% in Alzheimer's disease.

    This is very intriguing in light…

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    Oct 29, 2024 48 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    While Ozempic also bestowed 47% relative risk reduction to women, other GLP-1 receptor agonists slightly outperformed Ozempic in men (14% relative Alzheimer's disease risk).

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    Oct 29, 2024 30 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    The study compared Semaglutide (Commercially: Ozempic for diabetes, Wegovy for weight-loss) against 7 other type 2 diabetes medications for its ability to prevent Alzheimer's disease in older type 2 diabetes patients, a critical group with 65% higher risk for developing…

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    Oct 29, 2024 38 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Ozempic outperformed every other type 2 diabetes medication in preventing Alzheimer's disease, with a 78% and 52% risk reduction compared to insulin, in women and men, respectively.

    Oct 29, 2024 54 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Ozempic surpasses all other diabetes medications in preventing Alzheimer's disease in diabetics >60 years, effect is more pronounced in women, and independent of obesity.

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    Oct 29, 2024 2324 147 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    A recently published article in Alzheimer & Dementia (1) reported 7 target trial emulations (a highly standardized type of retrospective observational studies) analyzing the data of over 1 million type 2 diabetes patients over 60 (over 116 million Electronic Health Records EHRs…

    Oct 29, 2024 55 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @elonmusk @neuralink Agreed, a great application for the tech

    Oct 29, 2024 277 4 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    In Miami this week with heretics and health nuts. What if they had a baby?

    Oct 28, 2024 208 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Pretty soon, we’ll find out that thinking without the aid of AI will feel rather limiting.

    Oct 28, 2024 1488 76 View on X
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