3.iv/

The study reported a significant increase in biological age with Follistatin gene therapy, primarily driven by its effect on the PACE aging clock. I have received this therapy, which successfully boosted my circulating Follistatin levels. Upon getting the gene therapy my…

3.v/

I continuously trace my epigenetic biological age using the PACE (DunedinPACE) clock, as discussed this clock is superior in both reliability and sensitivity, especially in detecting shifts in biological age in healthy cohorts, all desirable features for a biological age…

3.i/

In September I stopped Rapamycin, based on concerns around its metabolic side-effects observed in my lab results (including increased cholesterol, blood sugar and RHR); the data here showed Rapamycin increased biological aging according to two clocks, while ineffective…

3.ii/

I continue to take Metformin, despite concerns based on its ineffectiveness in ITP mouse studies (2), and claims about it blunting muscle growth (3) (I am top 0.1% of my age-group for muscle volume) evidence from this study and from aging clocks in non-human primates (4),…

3.iii/

A green mediterranean diet fared best at reducing/slowing down aging as measured by 10 out of 16 aging clocks, this diet is the closest to my Blueprint diet. Also, I stick to a grain-free diet. The slight but significant acceleration in aging clocks observed with…

2/ These interventions demonstrated a significant increase or acceleration of Biological Aging

1. Pharmacological Interventions: Rapamycin (mTORC1 inhibitor, immunosuppressant), senolytics.

2. Supplements: Buckwheet Extract

3. Gene Therapies: Follistatin (myostatin…

3/ The findings are very reassuring regarding my health program and the Blueprint stack and some of the latest changes we introduced.

Many of the reported findings echo my protocol and system, which is fascinating as it indicates that continuous measurement and optimization for…

1/These interventions demonstrated a significant decrease or slow-down of Biological Aging

1. Pharmacological Interventions: Anti-TNF therapy (anti-inflammatory), Metformin (Anti-diabetes, AMPK activation),Ketamin (antidepressant psychedelic, dissociative).

2. Supplements:…

A new study is out: things that make you age faster, and slower, according to 16 epigenetic age clocks.

🧵

If you lift weights, you’ll be stronger.

If you eat well, you’ll have more energy.

If you drop bad habits, you’ll be more powerful.