2/ 1/ OpenAI × Retro: Breaking the Bottleneck To overcome these barriers, OpenAI built GPT-4b micro, a compact model derived from GPT-4o but specialized for protein design. Initialized from a scaled-down GPT-4o, GPT-4b micro was trained by blending protein sequences, structural
2/ 1/ OpenAI × Retro: Breaking the Bottleneck
To overcome these barriers, OpenAI built GPT-4b micro, a compact model derived from GPT-4o but specialized for protein design.
Initialized from a scaled-down GPT-4o, GPT-4b micro was trained by blending protein sequences, structural
3/ Key Results (AI-generated KLF4 and SOX2 vs. traditional OSKM Controls) Variant hit rate + Expert-driven design of OSKM: < 10% of engineered variants outperform wild-type. + GPT-4b micro: 30% of SOX2 and 50% of KLF4 variants outperformed wild-type. Pluripotency induction
3/ Key Results (AI-generated KLF4 and SOX2 vs. traditional OSKM Controls)
Variant hit rate + Expert-driven design of OSKM: < 10% of engineered variants outperform wild-type. + GPT-4b micro: 30% of SOX2 and 50% of KLF4 variants outperformed wild-type.
Pluripotency induction
0/ AI Redesigns the Engines of Cellular Reprogramming OpenAI and Retro Biosciences reported a landmark achievement: using a domain-specialized protein design model, GPT-4b micro, they created engineered reprogramming factors that deliver over 50× higher efficiency in generating
0/ AI Redesigns the Engines of Cellular Reprogramming
OpenAI and Retro Biosciences reported a landmark achievement: using a domain-specialized protein design model, GPT-4b micro, they created engineered reprogramming factors that deliver over 50× higher efficiency in generating
1/ 0/ From Yamanaka’s Discovery to Today In 2006, Shinya Yamanaka identified four transcription factors; Oct4, Sox2, Klf4, and c-Myc (OSKM), capable of resetting differentiated adult cells into a pluripotent, embryonic-like state. This breakthrough opened two revolutionary doors
1/ 0/ From Yamanaka’s Discovery to Today
In 2006, Shinya Yamanaka identified four transcription factors; Oct4, Sox2, Klf4, and c-Myc (OSKM), capable of resetting differentiated adult cells into a pluripotent, embryonic-like state. This breakthrough opened two revolutionary doors
This is big. OpenAI and Retro used a custom model to make cellular reprogramming into stem cells ~50× better, faster, and safer. Similar Wright brothers’ glider to a jet engine overnight. We may be the first generation who won't die. Let's take a look at what they did. 🧵
This is big. OpenAI and Retro used a custom model to make cellular reprogramming into stem cells ~50× better, faster, and safer. Similar Wright brothers’ glider to a jet engine overnight.
We may be the first generation who won't die.
Let's take a look at what they did. 🧵
I am very excited about the future. I have hope that AI will help us overcome the worst parts of human nature and elevate us to levels beyond our imaginations.
@HHS_Jim Jim you’re the perfect person for the job. Thank you for doing this hard and important work.
@nicdunz it's for more youthful skin. the objective is to rejuvenate every cell of the body to a more youthful state so any therapy that can push in that direction I pursue.
@SymuriaX yes, it's meant to off-set some aging effects in the skin and revitalize skin health to a more youthful state
Why I have leopard face Did a 1927 nm fractional non-ablative Thulium laser: + 50% resurfacing, neck + 40% resurfacing, face Expected results (1 session): +~25% improvement in pigment evenness + ~15% softening of fine lines +~15% improvement in overall texture
Why I have leopard face
Did a 1927 nm fractional non-ablative Thulium laser: + 50% resurfacing, neck + 40% resurfacing, face
Expected results (1 session): +~25% improvement in pigment evenness + ~15% softening of fine lines +~15% improvement in overall texture
