3/ Possible Chronic Disease Risk Reduction Cardiovascular Health: semaglutide a GLP-1-RA has shown promise of lifespan extension in obese individuals by reducing the risk of cardiovascular disease. (12) Preclinical evidence also indicates improved endothelial function via…
3/ Possible Chronic Disease Risk Reduction
Cardiovascular Health: semaglutide a GLP-1-RA has shown promise of lifespan extension in obese individuals by reducing the risk of cardiovascular disease. (12)
Preclinical evidence also indicates improved endothelial function via…
4/ My Microdosing Protocol To evaluate the potential benefits I will start a 12 week trial of the GLP-1/GIP RA Tirzepatide (Commercial name: Munjaro for diabetes, Zepbound for weight loss). I'll start with a weekly dose of 0.5 mg, that is 1/2 the typical microdose, and 1/5 of…
4/ My Microdosing Protocol
To evaluate the potential benefits I will start a 12 week trial of the GLP-1/GIP RA Tirzepatide (Commercial name: Munjaro for diabetes, Zepbound for weight loss).
I'll start with a weekly dose of 0.5 mg, that is 1/2 the typical microdose, and 1/5 of…
1/ Here’s what I’m doing and why: What is a GLP-1RA? A GLP-1-RA is a medication that mimics the hormone glucagon-like peptide-1, crucial for regulating blood sugar and appetite. They’re approved for managing type 2 diabetes and aiding in weight loss by reducing blood sugar…
1/ Here’s what I’m doing and why:
What is a GLP-1RA? A GLP-1-RA is a medication that mimics the hormone glucagon-like peptide-1, crucial for regulating blood sugar and appetite. They’re approved for managing type 2 diabetes and aiding in weight loss by reducing blood sugar…
2/ Metabolic and Longevity Benefits Metabolic Optimization: Less glucose spikes, lower insulin levels, and thus reduced advanced glycation end-products (AGEs) (4, 5). Anti-Inflammatory Effects: Systemic inflammation reduction by decreasing pro-inflammatory cytokines like TNF-α…
2/ Metabolic and Longevity Benefits
Metabolic Optimization: Less glucose spikes, lower insulin levels, and thus reduced advanced glycation end-products (AGEs) (4, 5).
Anti-Inflammatory Effects: Systemic inflammation reduction by decreasing pro-inflammatory cytokines like TNF-α…
I'm starting a new longevity protocol: microdosing Tirzepatide, a dual GLP-1/GIP receptor agonist. Here is the existing evidence, my protocol, measurement plan, and what I expect to achieve by this intervention. 🧵
I'm starting a new longevity protocol: microdosing Tirzepatide, a dual GLP-1/GIP receptor agonist.
Here is the existing evidence, my protocol, measurement plan, and what I expect to achieve by this intervention. 🧵
6/ Complete lack of credibility, or any trace of sound reasoning. The study does not mention “oils” “cooking oils” or “plant oils” even once, it does mention “the western diet” once, and mentions Linoleic Acid and Arachidonic Acid, but all in the introduction, where the authors…
6/ Complete lack of credibility, or any trace of sound reasoning.
The study does not mention “oils” “cooking oils” or “plant oils” even once, it does mention “the western diet” once, and mentions Linoleic Acid and Arachidonic Acid, but all in the introduction, where the authors…
7/ Sources 1. 2. 3. 4.
7/ Sources
1. 2. 3. 4.
4/ This study has nothing to do with nutrition, but even if it somehow did, meat rather than plan oils would be the main culprit Even assuming that this type of dysregulation is somehow driven by dietary intake, the problematic fat in this context is Arachidonic Acid, which is…
4/ This study has nothing to do with nutrition, but even if it somehow did, meat rather than plan oils would be the main culprit
Even assuming that this type of dysregulation is somehow driven by dietary intake, the problematic fat in this context is Arachidonic Acid, which is…
5/ Catastrophic example of “correlation is not causation” Whenever prospective or associative studies are mentioned, we get the “correlation is not causation” chorus. While interventional and longitudinal studies are definitely superior, most insights begin as correlations.…
5/ Catastrophic example of “correlation is not causation”
Whenever prospective or associative studies are mentioned, we get the “correlation is not causation” chorus.
While interventional and longitudinal studies are definitely superior, most insights begin as correlations.…
2/ Misrepresentation of a completely unrelated peer-reviewed article Daily Mail and this doctor wanted to jump on the bandwagon of unconfirmed bias against seed oil. However without credible evidence, they misrepresented a legitimate peer-reviewed story. Unfortunately, such…
2/ Misrepresentation of a completely unrelated peer-reviewed article
Daily Mail and this doctor wanted to jump on the bandwagon of unconfirmed bias against seed oil.
However without credible evidence, they misrepresented a legitimate peer-reviewed story.
Unfortunately, such…
