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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    6/ Health consequences of animal fats

    6.i/ Saturated animal fats

    In over 24,000 participants from the NHANES study, high saturated fatty acid intake was associated with an 8% increase in all cause mortality risk. A meta-analysis with over 1,100,000 total participants showed…

    Jan 9, 2025 38 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    7/ Disclaimer, next steps

    All evidence presented here is for natural, pure, clean, well-packaged and preserved plant seed oils, and does not apply to contaminated, poorly stored, or overheated seed oils (this was partially covered in my earlier thread).

    I will soon also tackle…

    Jan 9, 2025 40 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5.i/ Omega-6 PUFAs

    5.i.a/ All cause mortality

    Total PUFAs uptake (Omega-3&-6) was associated with 19% and 11% reduction of all cause mortality in a prospective cohort study with 25,000 participants and a meta-analysis with 1,164,029 participants, respectively. (5)

    Total PUFAs…

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    Jan 9, 2025 26 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4iii/ PUFA: Omega-6 and Omega-3

    Between PUFAs, we distinguish between Omega-3 and Omega-6 based on the relative position of the double bonds to the end of the molecule. This small difference has large biological consequences as it determines the metabolic and functional…

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    Jan 9, 2025 33 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/ Health consequences of unsaturated fats in plant seed oils

    Lets explore the clinical evidence for each of the major plant seed oil fats; MUFAs, Omega-6 and Omega-3 PUFAs.

    To simplify we will explore the implications of each plant oil fatty acid on lifespan (all cause…

    Jan 9, 2025 21 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4i/ Unsaturated vs Saturated fats

    Saturated fats (think butter) are solid at room temperature and are predominantly animal fats or coconut. While unsaturated fats are liquid at room temperature (unsaturated pertains to the presence of double bonds, which reduce their…

    Jan 9, 2025 26 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4ii/ MUFA and PUFA

    Olive oil is the most prominent example of MUFA rich oils (Oleic acid) as well as rapeseed.

    In contrast other seed oils, sunflower, nut, and grapeseed oils are all rich in PUFAs, specifically LA, an Omega-6 acid.

    Linseed oil and walnuts are rich in…

    Jan 9, 2025 33 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Understanding the fatty acid composition of cell membranes

    Cells are wrapped with fatty membranes, whose composition determines the fluidity, function, chemical reactivity (peroxidation rate), and cell signalling and communication. All this affects physiological functions…

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    Jan 9, 2025 44 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ Understanding the composition of plant oils

    4i/ Unsaturated vs Saturated fats
    4ii/ MUFA and PUFA
    4iii/ PUFA: Omega-6 and Omega-3

    Jan 9, 2025 27 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ Impartial evidence-based thinking vs loud shouting

    Nutrition is a complex topic, in large because of the many confounding factors surrounding any topic. Given the difficulty of getting all these under review, many fall back on simplified opinions that are more comfortable to…

    Jan 9, 2025 77 3 View on X
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