2. Three epigenetic clocks were used to assess the effect of outdoors ambient heat on biological aging

i. PHENOAge: measurement of biological age
ii. GrimAge: estimates mortality risk
iii. DunedinPACE: measures the speed of aging

Results

1. PhenoAge clock was most sensitive to heat exposure differences; both short and long term increases in ambient outside temperature correlated with increases in PHENOAge biological age according; around 1 extra year for short term differences and over 3 years of…

People living in hotter climates age faster

Published this week a study used three distinct epigenetic aging clocks to show that more hotter days on average (caution-level and extreme level heat) make you age faster. 🧵

Background

0/ The study tracked biological age in 3686 adults over 56 years across the US in relation to outdoor ambient heat exposure.

1. Comparisons were done for short and long-term differential exposure to outside heat based on daily heat index, as assessed by number of heat days: (heat caution= 80° to 90°F (26.7° to 32.2°C); 90° and 103°F (32.2° and 39.4°C)) as provided by the National Weather Service based…

@nicolasjammet Nicolas it's great seeing you bring some sanity to food

To address a few comments here, ahead of sharing my dosing protocol soon, it will be low-dose, well below 1 mg/kg to minimize risks of serotonin syndrome and oxidative stress. I’m not taking any other serotonergic medications or supplements (like SSRIs or 5HTP). Also, I'll be…

@agy_lena I think about this all the time. So many sad disease states that don’t get dedicated focus and resources. And so much low hanging fruit everywhere.

I’m off to bed gn friends

@Grimezsz bryan ai will help grimes hi and grimes ai to get music hw done on time so that we can rage at your next set