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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/ Internally PACE has gained our trust by validating what we learned via years of rigorous biomarker testing.

    Here are examples of how PACE results retrospectively aligned with our strategic decisions:

    + Rapamycin cessation: We stopped my rapamycin protocol due to observed…

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    Apr 30, 2025 44 4 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ PACE aces every benchmark

    According to recent pre-prints and previous research, the PACE biological aging clock demonstrates strong reliability:

    + It accurately detects an increased speed of aging following interventions known to accelerate aging, such as chemotherapy and…

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    Apr 30, 2025 38 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ How Biological Aging clocks gained a bad reputation

    The early adoption of epigenetic aging clocks inadvertently led to a body of literature containing inconsistent and conflicting biological age measurements across various interventions.

    This was largely because earlier…

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    Apr 30, 2025 35 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Two new pre-prints take a new approach to restore confidence to the field.

    A research team at Yale supported by TruDiagnostic is working to standardize the emerging field of epigenetic biological aging. To reliably benchmark and compare epigenetic aging clocks for assessing…

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    Apr 30, 2025 35 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Speed of aging (PACE) is one of the most clinically validated aging markers.

    My team and I use it extensively to measure the efficacy of health protocols.

    This thread explains how biological aging clocks gained a bad reputation and how two new pre-prints take a new approach…

    Apr 30, 2025 65 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ Addressing Skepticism:

    There's been some skepticism surrounding biological age clocks. I'm going to address the arguments around epigenetic age measurements, explain why these concerns don't apply to PACE (the clock my team and I use), and discuss the new standards emerging…

    Apr 30, 2025 43 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    This marker reveals how fast you’re aging.

    + New science just emerged to support it
    + It’s based on DNA methylation
    + It allows me to know what is and isn’t working

    Here’s an overview of how:
    + it works
    + you can find out your result
    + you can compare your results to others

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    Apr 30, 2025 1153 70 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Should I let Evening Bryan out tonight?
    He over eats. Doom scrolls. Skips bedtime.
    Wdyt?

    Apr 30, 2025 2504 38 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I really wish I'd had someone in my life encouraging me to prioritize my health versus martyr myself.

    But there was literally no one. This is what I'm trying to do for you.

    Apr 29, 2025 4401 133 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @sal_habash HRV last night was 70. overall my HRV is about average for my age, it's been one of the most stubborn markers to rejuvenate.

    Apr 29, 2025 55 0 View on X
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