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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    We have a very serious situation on our hands as a species. It is not clear that we will survive the coming years and decades.

    Some think the fear is misguided.
    Others think we don't fear enough.

    Where do you land?

    May 22, 2025 1443 40 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Sleep deprivation lowers testosterone and reduces semen volume. Men who sleep fewer than 6 hours per night produce sperm with significantly reduced motility and morphology.

    May 22, 2025 920 38 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/ Allulose is present in the following Blueprint Products

    Longevity mix 2g/serving
    Longevity protein 5g/serving
    Metabolic protein 2g/serving
    Macadamia Protein bars

    The full blueprint stack provides a daily dose of 9 grams of allulose (excluding the optional protein bars),…

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    May 22, 2025 73 5 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @sivori Yesterday I did 140 °F instead of 200 °F and could barely feel the heat. Cool to see how fast the body adapts.

    May 22, 2025 55 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Research indicates several mechanisms for these benefits, overlapping with several longevity medicines

    An in-vitro model showed that allulose slowed down the digestion of carbohydrate and resulting glucose release and absorption (similar mechanism to acarbose, a diabetes drug…

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    May 22, 2025 43 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ Additional metabolic and health benefits

    Obesity, fat loss and weight control

    A trial involving 121 overweight/obese adults in Korea showed that a higher allulose dose of 14 g/day correlated to a reduction in BMI, body fat percentage and total fat mass, especially visceral…

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    May 22, 2025 71 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ Safety of allulose

    Concerns regarding allulose mainly revolve around potential gastrointestinal issues, including severe diarrhea. However, a clinical study involving 30 adults (15 women and 15 men aged 21-30) determined that allulose was well-tolerated without digestive…

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    May 22, 2025 44 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ Reduced blood glucose and improved insulin response

    Allulose reduced blood sugar when ingested with other carbohydrates, signifying an effect in improving insulin sensitivity and blood glucose disposal.

    A 2023 systematic review and meta-analysis of human trials found that…

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    May 22, 2025 39 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Allulose is perhaps the most longevity-friendly sweetener. 🧵

    Here's why:
    + it's safe
    + multiple health benefits
    + reduced blood glucose
    + metabolic benefits including fat loss, increased GLP1 secretion, liver health, teeth protection.

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    May 22, 2025 1303 83 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ What is Allulose?
    Allulose is a rare sugar found naturally in fruits like figs and raisins. It is nearly calorie-free (0.2-0.4 kcal/g) because it is absorbed and excreted through urine without being metabolized by the human body. The minimal calorie contribution is attributed…

    May 22, 2025 82 1 View on X
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