6/ The identified key genes also have associations with phenotypes and conditions that are linked to accelerated brain aging including: increased BMI, high blood pressure, smoking, asthma, Alzheimer and Parkinson disease. Some specific examples + MAPT correlated with increased…
6/ The identified key genes also have associations with phenotypes and conditions that are linked to accelerated brain aging including: increased BMI, high blood pressure, smoking, asthma, Alzheimer and Parkinson disease.
Some specific examples + MAPT correlated with increased…
0/ Published last week in @ScienceAdvances a study reported the use of brain scans with multiple deep learning models combined with gene expression analysis in blood samples and brain tissues from to identify genes that drive brain aging.
Background and details 1/ The study used brain scans and gene expression analysis data from 38,961 subjects from the UK Biobank, 6637 of which with a diagnosed brain disorders with “healthy” brains.
Background and details
1/ The study used brain scans and gene expression analysis data from 38,961 subjects from the UK Biobank, 6637 of which with a diagnosed brain disorders with “healthy” brains.
2/ The study aimed to match structural (MRI) and genetic insights into brain aging to guide drug repurposing for delaying and slowing down brain aging and related disorders.
3/ The analysis of brain MRI scans using 7 deep learning models yields an estimation of the biological age of the brain, Brain Age Gap BAG, the estimated gap between chronological and brain biological age.
Study uses MRI ad machine learning to estimate brain age, and identifies 64 “druggable” genes that drive brain aging
5/ I'll be posting soon about what you can do to improve sperm health.
4/ Abnormal sperm parameters correlate with a shorter life expectancy A study involving 11,935 men evaluated for infertility found that men with abnormal sperm parameters had higher mortality rates. Men with two or more abnormal sperm parameters had a 2.3 fold increase in all…
4/ Abnormal sperm parameters correlate with a shorter life expectancy
A study involving 11,935 men evaluated for infertility found that men with abnormal sperm parameters had higher mortality rates. Men with two or more abnormal sperm parameters had a 2.3 fold increase in all…
2/ Poor sperm counts predict lower testosterone levels and poor metabolic health. A study involving 5177 found that men with a total sperm count of below 39 million per ejaculate were 12 times more likely to have abnormally low testosterone levels. Moreover, men with low sperm…
2/ Poor sperm counts predict lower testosterone levels and poor metabolic health.
A study involving 5177 found that men with a total sperm count of below 39 million per ejaculate were 12 times more likely to have abnormally low testosterone levels. Moreover, men with low sperm…
3/ Poor sperm quality predicts higher risk of age-related chronic disease and addiction A study comparing 13,027 men with semen-related infertility to 23,860 men with no semen abnormalities showed that men with abnormal semen parameters (male factor infertility) had 30% and 48%…
3/ Poor sperm quality predicts higher risk of age-related chronic disease and addiction
A study comparing 13,027 men with semen-related infertility to 23,860 men with no semen abnormalities showed that men with abnormal semen parameters (male factor infertility) had 30% and 48%…
