@eimisja please report back completion

@jaxonparrott despite our best efforts, this variability will occur. that you know and are aware is great.

@michaeltlasley sometimes in pinch, suboptimal trade offs need to be made. a good question to ask is whether the decision was necessary.

Confess your debauchery

7/ 466 drugs were identified that can counteract the effects of 29 genes out of the the 64 genes identified to drive brain aging. Of these 29 drugs have shown some effect in clinical trials in counteracting brain aging, and 20 are considered geroprotectors (anti aging drugs).…

Significance

8/ These results demonstrate the viability of a dual structural and genetic approach to measuring brain aging and identifying targets that can slow it down. The study managed to independently validate various genetic pathways and drugs with known clinical efficacy…

9/ Drug repurposing is an attractive strategy to identify promising tools against aging and age related disease, at a fraction of the cost and effort required to discover and develop entirely new therapeutic agents.

4/ The analysis of BAG scores against gene expression patterns of participants blood and brain tissues identified genes that are likely to drive brain aging.

5/ 64 genes were identified with causal relationships to brain aging, of which 37 and 7 genes were validated as having two and three pieces of genetic evidence supporting their effect, respectively.

6/ The identified key genes also have associations with phenotypes and conditions that are linked to accelerated brain aging including: increased BMI, high blood pressure, smoking, asthma, Alzheimer and Parkinson disease.

Some specific examples
+ MAPT correlated with increased…