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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    6/ Brain rejuvenation and cognitive enhancement

    Study design and conditions

    Participants: 13 healthy individuals and 16 with mild cognitive impairment (MCI).

    Protocol: 3 weeks, 4 weekly sessions.

    Session Structure: Alternating 5-minute intervals: four at 12% O2 (hypoxia) and

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    Aug 5, 2025 6 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Efficacy Assessment Metrics:

    + Hypoxia Efficacy: Real-time device tracking (SpO2%), blood pyruvate/lactate.

    + Sleep and Recovery: Sleep tracking, resting heart rate (RHR), heart rate variability (HRV) with sympathetic/parasympathetic index (SDNN, RMSSD, HF/LF).

    + Fitness,

    Aug 5, 2025 3 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ Here is some of the clinical evidence supporting HIIT role as a longevity and performance boosting intervention

    Performance and recovery

    Enhanced recovery in over-trained endurance athletes
    A study involving 15 endurance athletes diagnosed with overtraining syndrome.

    IHHT

    Aug 5, 2025 1 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/ IHHT preconditioning reduced muscle damage following intense resistance training

    Double-blind, randomized, crossover study involving 11 young male athletes.

    Intervention (Pre-exercise): Participants completed either a Normoxia (N) trial or a Hypoxia–Hyperoxia (IHHT) trial.

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    Aug 5, 2025 1 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ My protocol

    I will be using MitoVit system.

    MitoVit utilizes a biofeedback mechanism to adjust the oxygen percentage in the delivered air, targeting specific blood oxygen saturation (SpO2%) levels.

    As the protocol progresses, lower SpO2% values are targeted for a gradual

    Aug 5, 2025 2 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ Here is my IHHT protocol:

    + 35 days total
    + 26 biofeedback training sessions
    + 3:1 rhythm: three training sessions,one recovery

    Cycle per Session (Biofeedback Mode):
    + 5 minutes training (hypoxia: SpO2 85→77%)
    + 3 minutes recovery (adaptive hyperoxia, 99% SpO2)
    + 5 cycles

    Aug 5, 2025 2 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Starting a new protocol: IHHT

    + alternates low and high oxygen
    + igniting mitochondria and boosting cellular energy
    + raising red blood cells and repairing vessels
    + accelerating recovery and improving cognition
    + slowing speed of aging

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    Aug 5, 2025 74 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @stats_feed It's a bit more nuanced than this.

    A pre-print making the rounds claims Ozempic “reverses aging,” but the data don’t support that headline.

    Researchers reanalyzed an old 32-week trial in just 84 HIV patients who had developed extreme bellyfat from their antiretroviral

    Aug 5, 2025 1 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ Why This Matters:

    + Muscle volume and body composition are highly predictive markers for long-term health and longevity.

    + Muscle Mass (Volume) and Longevity: For older adults (>55 years), being in the top 25% for muscle mass reduced all-cause mortality risk by 19% compared

    Aug 5, 2025 0 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ Breakdown of my body composition improvements over the past 9 months Oct 2024 → Jul 2025:

    Muscle Volume:

    Total (bi-lateral) thigh muscle volume: Increased by 0.4%, from 18.02 to 18.10 liters, placing me in the top 1%. While muscle volume typically peaks between ages 30-35

    Aug 5, 2025 0 0 View on X
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