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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Did you know "sugar face" is a thing?

    Sugar leads to AGEs which leads to the yellowing of skin (“sugar face”) due to glycation-induced crosslinking.

    AGEs visibly degrade skin quality:
    + Collagen stiffens, your skin loses elasticity, leading to wrinkles.
    + Elastin breaks down…

    May 19, 2025 1304 93 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    An extended family member of mine was diagnosed with an aggressive cancer. He has days to live.

    Regular testing and early detection is the best way to avoid this.

    May 19, 2025 4736 86 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ HBOT reduced my blood p-TAU217 by 28% from 0.14 to 0.10 pg/mL.

    0.15 pg/mL is considered the upper range of healthy.

    May 19, 2025 39 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ The FDA has just approved the marketing of Lumipulse G test, which uses pTAU217/A𝛃42 as the first blood test for early detection of Alzheimer disease in people over 55, showing symptoms for the disease.

    May 19, 2025 22 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ The marker has strong prognostic value in healthy people as well. A study found a simple p-Tau217 blood test to be equally predictive of future cognitive decline risk to much more complex brain imaging of Tau-tangles.

    May 19, 2025 18 0 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Cognitively unimpaired individuals in the highest 25% of pTau217 levels demonstrated a 57% elevated risk of future cognitive decline. This is comparable to the 61% increased risk observed in those with the highest 25% of Tau accumulation in pertinent brain areas (a…

    May 19, 2025 34 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    HBOT reduced a future dementia marker of mine by 28%.

    Details:
    + pTAU217 just got FDA-cleared for early Alzheimer’s screening. It also has prognostic value for healthy brains.

    + The FDA just approved approved pTAU217/A𝛃42 ratio as the first blood test for the early…

    Tweet media
    May 19, 2025 596 35 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Phosphorylated tau protein (p-TAU217) is a disease marker that accumulates as tangles in the brains of individuals with Alzheimer's disease. Elevated concentrations of p-TAU217 can also be detected in the blood, higher concentrations predict faster disease progression.

    May 19, 2025 30 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Skip the late latte.

    Caffeine after 2 PM can delay melatonin by hours. That means tossing, turning, and feeling wired when your body wants rest.

    May 19, 2025 1509 61 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    All my efforts around health, anti-aging and Don't Die are 100% about the human race living past the superintelligence event horizon.

    May 19, 2025 1884 71 View on X
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