Plant seed oils are abundant in modern diets, they have gained a notorious reputation for driving age related diseases. But is this reputation fair? Or is there more to the story? Let's take a careful look at the science. 🧵
Plant seed oils are abundant in modern diets, they have gained a notorious reputation for driving age related diseases.
But is this reputation fair? Or is there more to the story?
Let's take a careful look at the science. 🧵
1/ Various claims have been made regarding alleged harms of excessive seed oils consumption: i) Accelerated aging, and premature death ii) Increasing cholesterol levels and cardiovascular disease CVD risk iii) Promoting systemic inflammation iv) Increased risk of diabetes v)…
1/ Various claims have been made regarding alleged harms of excessive seed oils consumption:
i) Accelerated aging, and premature death ii) Increasing cholesterol levels and cardiovascular disease CVD risk iii) Promoting systemic inflammation iv) Increased risk of diabetes v)…
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Who do you think would do well as the Director of the National Institute on Aging (NIA)?
9/ Sources 1. 2. 3. 4. 5. 6. 7. 8.
9/ Sources
1. 2. 3. 4. 5. 6. 7. 8.
8/ End Note: Aging clocks are mostly a proxy (surrogate endpoint) for the actual endpoint of interest, which is lifespan itself (mortality data). Relying solely on mortality data would delay the field by several decades. Since aging clocks were not specifically designed to…
8/ End Note:
Aging clocks are mostly a proxy (surrogate endpoint) for the actual endpoint of interest, which is lifespan itself (mortality data). Relying solely on mortality data would delay the field by several decades.
Since aging clocks were not specifically designed to…
6/ Sensitivity of Aging Clocks in Health and Disease Interventions For the longevity field, aging clocks that can detect changes in biological age in healthy people are of particular value. Improvemeents from treating a disease are usually greater in magnitutde and easier to…
6/ Sensitivity of Aging Clocks in Health and Disease Interventions
For the longevity field, aging clocks that can detect changes in biological age in healthy people are of particular value. Improvemeents from treating a disease are usually greater in magnitutde and easier to…
7/ Organ-System Clocks, and Proxy Epigenetic Markets of Metabolites and Proteins are Reliable in Predicting intervention Effects, including Diets. The latest generation of epigenetic aging clocks is called Gen X (for generation explainable), they aim to make biological age…
7/ Organ-System Clocks, and Proxy Epigenetic Markets of Metabolites and Proteins are Reliable in Predicting intervention Effects, including Diets.
The latest generation of epigenetic aging clocks is called Gen X (for generation explainable), they aim to make biological age…
4/ Results validate some longevity interventions, but mostly indicate a wide gap in the systemic understanding of other interventions and the reliability of "single aging clock approaches" and animal data in assessing longevity outcomes in humans. Metformin has long been of…
4/ Results validate some longevity interventions, but mostly indicate a wide gap in the systemic understanding of other interventions and the reliability of "single aging clock approaches" and animal data in assessing longevity outcomes in humans.
Metformin has long been of…
5/ Evaluation of Aging Clocks' Reliability and Sensitivity Shows the Potential of the DunedinPACE Clock Beyond validating interventions, the authors also assessed the reliability and sensitivity of the 16 tested aging clocks by comparing them to one another and gauging how often…
5/ Evaluation of Aging Clocks' Reliability and Sensitivity Shows the Potential of the DunedinPACE Clock
Beyond validating interventions, the authors also assessed the reliability and sensitivity of the 16 tested aging clocks by comparing them to one another and gauging how often…
