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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ Exercise rejuvenates the brain and enhances cognitive function

    High intensity exercise: enhanced neuronal plasticity and health (e.g. BDNF secretion) and vascularization (VEGF), enhanced neuronal rejuvenation (e.g. hypothalamus). Enhancing circulation, especially aerobic…

    Feb 13, 2025 81 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Sleep and exercise synergize to optimize cognition and brain health

    Both sleep and exercise improve cognition and maintain brain function and health.

    Good sleep enables better exercise as it improves neuronal plasticity, while lack of sleep diminishes exercise cognitive…

    Feb 13, 2025 111 10 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ The hormonal interplay of sleep and exercise

    Regular exercise helps fine tune cortisol/melatonin levels to improve sleep (high intensity exercise earlier in the day, avoid going to bright gyms at night)

    Growth hormone is essential for realizing muscle recovery repair and…

    Feb 13, 2025 130 8 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    2/ One night of complete sleep deprivation increased blood S100-B and NSE by 20%, S100-B both markers of traumatic brain damage and stroke.

    Feb 13, 2025 70 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Quality sleep is essential for learning and memory consolidation

    A balanced sleep cycle is required for memory consolidation.

    Deep sleep: allows filtering through the short term memories and learnings of the day, and the selection of most significant memory bits to be…

    Feb 13, 2025 89 7 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I don't want to do this, but you need to hear this.

    Sleep deprivation lowers IQ, increases toxic beta-amyloid buildup, and raises brain damage markers linked to stroke.

    Learn how high quality sleep boosts the brain.
    🧵

    Tweet media
    Feb 13, 2025 2893 298 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Sleep deprivation is brain damage

    Shorter sleep correlated with lower IQ-test performance in school children.

    Feb 13, 2025 117 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ A single night of sleep deprivation increased beta amyloid load in the brain by 5%, this is the plaque-causing protein beta-amyloid in the brain by 5%.

    Feb 13, 2025 74 3 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    There's many focused on the short term; enough of us need to think on the very long term.

    Feb 13, 2025 777 29 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Do this structured daydream for 15 min today:

    close your eyes, relax, and imagine you're an alien that's just arrived on earth. What do you observe?

    A cheeky answer is fine, also, spend 15 min as it sharpens creativity, reduces stress, and strengthens memory.

    Feb 13, 2025 1009 41 View on X
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