1/ 0/ From Yamanaka’s Discovery to Today

In 2006, Shinya Yamanaka identified four transcription factors; Oct4, Sox2, Klf4, and c-Myc (OSKM), capable of resetting differentiated adult cells into a pluripotent, embryonic-like state. This breakthrough opened two revolutionary doors

This is big. OpenAI and Retro used a custom model to make cellular reprogramming into stem cells ~50× better, faster, and safer. Similar Wright brothers’ glider to a jet engine overnight.

We may be the first generation who won't die.

Let's take a look at what they did. 🧵

I am very excited about the future. I have hope that AI will help us overcome the worst parts of human nature and elevate us to levels beyond our imaginations.

@HHS_Jim Jim you’re the perfect person for the job. Thank you for doing this hard and important work.

@nicdunz it's for more youthful skin. the objective is to rejuvenate every cell of the body to a more youthful state so any therapy that can push in that direction I pursue.

@SymuriaX yes, it's meant to off-set some aging effects in the skin and revitalize skin health to a more youthful state

Why I have leopard face

Did a 1927 nm fractional non-ablative Thulium laser:
+ 50% resurfacing, neck
+ 40% resurfacing, face

Expected results (1 session):
+~25% improvement in pigment evenness
+ ~15% softening of fine lines
+~15% improvement in overall texture

what I'm eating this labor day weekend

3/ Full recovery is anticipated within a complete semen generation cycle (spermatogenesis cycle), approx 10 weeks.

Direct experiments on dry sauna and fertility markers haven't been reported, but clinical studies have shown the time-resolved effects of transient (localized heat

1/ One week post re-icing: misleading partial recovery (values compared to pre-sauna baseline)
total motile count ↓2%
motility ↓ 34%
total count ↑ 56%

4 weeks post re-icing: 2nd wave of heat effects: large drop in count, motility.
total motile count ↓ 56%
motility ↓ 50%