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  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @tferriss You guys better be saying:
    1. Sleep is your # 1 life priority.
    2. Exercise every day.
    3. Eat nutritiously and dump the junk.
    4. Friends & family.

    Most importantly: we will be the first generation who won't die. A new era of being human is here.

    Mar 5, 2025 3996 182 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    5/ Experimentally, PACE has surpassed other epigenetic biological aging clocks

    Best predictor of mortality and age related decline compared to earlier clocks.

    Best for evaluating interventions for their effect on biological aging: In a recent evaluation of 16 biological aging…

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    Mar 5, 2025 67 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4.iii/ Interpreting your PACE score

    Think of this as the rate at which your body is aging, it is the speed at which your body and cells are epigenetically aging, in other words it represents the speed at which your cells are accumulating methylation changes associated with…

    Mar 5, 2025 81 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    3/ Accurate DNAm surrogate markers (or Biomarker Proxies) further validates DNA-methylation and epigenetic aging as reliable health markers.

    The first three generations of clocks focused on “abstracting” epigenetic aging into a single number predicting chronological age, overall…

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    Mar 5, 2025 67 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    4/ This is why PACE is better than earlier generations of epigenetic age clocks?

    PACE has higher association size with both physiological and self-assessed health markers.

    PACE score predicts the physiological, structural, and biochemical markers of aging and damage in the…

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    Mar 5, 2025 75 1 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    0/ Biological Aging is mostly driven by the environment, habits and lifestyle choices and is malleable to interventions.

    Unlike chronological aging, biological aging is malleable and is a direct outcome of your behaviour and lifestyle choices. A seminal study in over 2000 twins…

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    Mar 5, 2025 205 16 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    1/ What are DNA methylation biological aging clocks?

    DNA methylation is a process where methyl groups are added to DNA, acting like switches that can turn genes off (other epigenetic switches are on-switches, like DNA acetylation).

    This affects how our cells read and express…

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    Mar 5, 2025 100 2 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    I am aging slower than anyone in the world.
    #1 in a fierce competition among 5,677.
    My score is off the charts.
    And I'm genetically disadvantaged.

    What does this even mean? 🧵

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    Mar 5, 2025 3531 150 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    Here's the test if you want to compete. You'll get:
    + speed of aging
    + a biological age of 11 organs including lung, heart, brain, hormone, metabolic, musculoskeletal, blood, liver, inflammation, kidney, and immune system
    + a guide on how to lower your speed of aging

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    Mar 5, 2025 196 6 View on X
  • Bryan Johnson
    Bryan Johnson @bryan_johnson

    @WellnessSageNow good job. my protocol doesn't cost millions. That's what I invested in a team to deep dive the science and conduct all initial and ongoing biological measurements on my. The actual protocol is low cost and mostly free: sleep, exercise and nutrition.

    Mar 5, 2025 114 4 View on X
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